What question should be asked to determine family history regarding a disease?

To effectively determine family history regarding a disease, asking whether anyone in the family has had the disease is crucial. This question directly pertains to the genetic and environmental factors that may contribute to an individual's susceptibility to that disease. Family history is a significant risk factor for many conditions, and understanding it helps healthcare professionals assess potential hereditary influences, which can guide diagnosis, management, and preventive measures.

The other options, while relevant to understanding the disease, do not directly address family history. Inquiring about available treatments pertains to medical management, assessing symptoms focuses on the individual’s current health status, and asking about the age of diagnosis relates to personal medical history rather than familial patterns.