BioBeyond – Disease Detective Practice Exam

In this scenario, the reason why it is understood that Ami cannot inherit hemophilia relates to the genetic basis of the condition. Hemophilia, specifically type A and type B, is typically inherited in an X-linked recessive pattern. This means that for a male (who has one X and one Y chromosome) to have hemophilia, he must inherit the mutated gene on his X chromosome. Females (with two X chromosomes) can be carriers if they have one normal and one mutated gene, but they would usually show symptoms only if both X chromosomes carry the mutation.

If Ami is considered not to inherit hemophilia in a certain context, it would imply that she does not carry the necessary genetic mutation on her X chromosomes. However, without additional context—such as Ami's biological sex or family medical history—the answer may vary.

The correct choice implies that there are foundational genetic principles that affect whether an individual can inherit hemophilia, and in a case where inheritance is not possible, that person would not be affected by the disorder. This highlights the importance of understanding genetic inheritance patterns in conditions like hemophilia.